celluloid, pix, hexchat, hypnotix, rhythmbox, LibreOffice
Those applications uninstalled just fine without any dependency issues last time I tried Mint.
If you’re unsure, make a snapshot of your current VM state (if your VM software supports it). Then just uninstall the junk you don’t need until Mint breaks. Restore snapshot, test some more, and so on. Those on real hardware should use Timeshift to create snapshots.
Tip: Run sudo apt autoremove package
in the terminal so you can see which dependencies that are removed.
On Ubuntu I use the tar.bz2 version to not have to deal with snaps or extra repositories. Also on Debian Stable to get the latest version.